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Additional BsAbs targeting CD20×CD3 (e.g., glofitamab) and B-cell maturation antigen ×CD3 (e.g., teclistamab) have shown robust activity in lymphoma and multiple myeloma, further underscoring the breadth of this platform across hematologic cancers [32, 33]

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The quantitative polymerase chain reaction and western blot experiments confirmed that BMI-1 expression was markedly increased in SKOV3 spheroids compared with their adherent counterparts and was downregulated by DHA treatment in spheroid SKOV3 cells (Fig